松花粉对环磷酰胺增效减毒作用研究

摘要

Objective To investigate the synergism and attenuation effects of Pini Pollen on cyclophosphamide chemotherapy in model mice.Methods The models of mouse were induced with S180 tumor and cyclophosphamide.The tumor inhibiting rates, hematology, Liver function, giant cell phagocytosis, hemolysin level and indexes of thymus and spleen were determined to evaluate the synergism and attenuation effects of Pini Pollen(150,300,600 mg/kg) on cyclophosphamide chemotherapy.Results Compared with cyclophosphamide chemotherapy group,the tumor inhibiting rates,white blood cell number,giant cell phagocytosis, hemolysin level and indexes of thymus and spleen were increased, at the same time liver function damage were alleviated significantly in cyclophosphamide plus Pini Pollen groups.Conclusions Pini Pollen has a remarkable synergism and attenuation effects on cyclophosphamide chemotherapy through its immune adjustment functions.%目的 研究松花粉对环磷酰胺化疗有无增效和减毒作用.方法 采用腹水型 S180 小鼠为实验系统,通过检测抑瘤率、血液学和肝功能指标,评价松花粉对环磷酰胺化疗的增效和减毒作用;采用免疫低下小鼠模型为实验系统,通过检测巨细胞吞噬功能、溶血素水平和胸腺、脾脏指数,评价松花粉的免疫调节作用.结果 松花粉(150、300、600 mg/kg) 与环磷酰胺合用后抑瘤率明显提高,可明显抑制环磷酰胺引起的白细胞下降和肝功能的损伤,可提高免疫低下小鼠单核吞噬细胞的吞噬功能、溶血素水平和免疫器官系数.结论 松花粉可通过调节免疫对环磷酰胺化疗起到明显的增效减毒作用.