Objective:To investigate the postoperative analgesic effects of parecoxib sodium combined with infraclavicular brachial plexus block on patients undergoing hand surgery. Methods:One hundred patients undergoing hand surgery were selected and randomly divided into two groups (n = 50): the parecoxib sodium group (Group P) and the control group (Group C). After the success of infraclavicular brachial plexus block, patients in Group P were administered one bolus of parecoxib sodium (40mg, diluted by 2mL N. S. ) intravenously 15 minutes before the beginning of operation, while those in Group C were injected N. S. by the same volume. VAS (visual analogue scale) was performed at postoperative 6, 8, 12 and 24 hours respectively, meanwhile, time and VAS to first pain, the number of patients demanded painkiller, time and VAS to first analgesia demanded were recorded and the adverse reactions were observed as well within 24h after operation. Results: The VAS scores at postoperative 8 and 12 hours, the number of patients demanded painkiller,the VAS score to first analgesia demanded were all less in Group P than those in Group C (P＜0. 05), while there was no significant difference in incidence of adverse reactions between the two groups within 24h after operation (P＞0. 05). Conclusions.. Parecoxib sodium combined with infraclavicular brachial plexus block is safe and effective on postoperative analgesic effects after hand surgery. Parecoxib sodium could be a good choice of perioperative multimodal analgesia techniques.%目的:探讨帕瑞昔布钠联合锁骨下臂丛神经阻滞用于手外科患者术后镇痛的有效性及安全性.方法:择期行单侧肘关节以下小手术患者100例,随机分为帕瑞昔布钠组(P组)和对照组(C组),每组50例.锁骨下臂丛神经阻滞实施成功后,P组于手术实施前15 min静脉注射帕瑞昔布钠40 mg(用0.9%氯化钠液2 mL稀释),C组给予等体积0.9%氯化钠液.分别于术后6 h、8 h、12 h、24 h进行视觉模拟(VAS)疼痛评分,记录最早出现疼痛的时间及VAS疼痛评分,术后24 h内要求镇痛的患者数,首次用镇痛药的时间及VAS疼痛评分,并观察术后不良反应的发生情况.结果:患者术后8 h、12 h的VAS疼痛评分、术后24 h内要求镇痛的患者数及首次要求镇痛时的VAS疼痛评分P组均低于C组(P<0.05).而2组患者术后不良反应的发生情况相似,差异无统计学意义(P>0.05).结论:帕瑞昔布钠联合锁骨下臂丛神经阻滞用于手外科患者术后镇痛安全、有效.
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