目的：研究帕瑞昔布钠联合臂丛麻醉对断肢（指）术后镇痛的临床疗效。方法：选择择期进行上肢断肢（指）再植手术的患者60例，按照双盲法随机分为两组：超前镇痛组（30例）为麻醉成功后立即给予帕瑞昔布钠40mg（生理盐水稀释2mL）；对照组（30例）给予安慰剂生理盐水2mL作对照，观察两组患者术后PCIA的芬太尼用量、MAP、HR、疼痛（ NRS）评分及不良反应发生率。结果：超前镇痛组的芬太尼用量明显低于对照组，镇痛有效率较对照组高，且不良反应发生率显著低于对照组。结论：瑞昔布钠联合臂丛麻醉对断肢（指）术后镇痛在效果和安全性上均有明显的优势。%Objective:To investigate the clinical efficacy of parecoxib sodium combined with brachial plexus anesthesia on postoper -ative analgesia after replantation of severed limb (finger).Methods:60 cases of patients received upper limb (finger) replantation sur-gery were selected and randomly divided into two groups:preemptive analgesia group (30 cases) were given 40 mg parecoxib sodium immediately after success anesthesia;control group (30 cases) received 2mL saline as placebo .We observed the fentanyl consumption , MAP, HR, pain ( NRS) score and the incidence of adverse reaction in three groups of patients after surgery.Results:The fentanyl con-sumption in preemptive analgesia was significantly lower than control group , the analgesic efficiency were significantly higher than con-trol group, while the incidence of adverse reactions was significantly lower than control group.Conclusion:The parecoxib sodium com-bined with brachial plexus anesthesia on limb (finger) postoperative analgesia has obvious advantages in efficacy and safety.
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