女性 Lynch综合征相关恶性肿瘤的诊治研究进展

摘要

Lynch综合征(LS)是一种常染色体显性遗传病,常表现为多系统多发恶性肿瘤.随着分子遗传学检测技术的快速发展,其检出率逐年增高,并为LS相关恶性肿瘤的监管及治疗提供了更为科学的诊疗方案,但作为一种系统性疾病,目前的研究多局限于各临床专科,对其综合评价和系统性随访尚不完善.该综述总结了女性LS患者相关恶性肿瘤的筛查诊断、治疗管理的新进展,为不同临床学科对Lynch综合征病患及家系的管理和治疗提供借鉴和帮助.%Lynch syndrome (LS) is an autosomal dominant inherited disease ,which usually presented as multi－system tomorigenesis.The detection rate increased with the fast development of molecular genetic methods ,this allowed more scientific care program for LS related cancers to be performed.As a systematic disease,studies of LS were common－ly confined in clinical department ,which limits complex evaluation and systematic follow－up in LS.In our study,we sum－marize developments in screening ,diagnosis and health care of female LS patients ,to provide assistance in the manage－ment of LS patients and their family and offer some guidence about the therapy for each clinical department .