Purpose To detect the MMP-9 and TIMP-1 expression in Uiglnir pregnancy-induced hypertension ( PIH ) placenta and to analyze their relevance to PIH. Methods Placental tissues were collected in 90 cases of Uighur pregnancy woman in Xinjiang Autonomous Region People s Hospital during Dec. 2008 - Sept. 2009, including 30 patients with severe pre-eclampsia, 30 mild pre-eclampsia and, 30 normal pregnancies. Results Placental distribution of MMP-9 and TIMP-1 expression was identical, mainly in the cytoplasm of trophoblastic cells, vascular endothelial cells and villous stromal cells. Positive staining of MMP-9 in the severe pre-eclampsia groups decreased. The MMP-9 expression in the severe pre-eclampsia was also significantly lower than that in the other groups ( P ＜ 0. 000 1 ). Among severe pre-eclampsia groups, normal group and mild group, there were statistically significant differences in the expression of MMP-9. The positive rates of MMP-9 become lower with severity state of illness. There was no significant difference in TIMP-1 expression among all the groups. The positive rates of MMP-9/TIMP-1 in the severe pre-eclampsia groups were lower than that of control groups and mild groups. The positive rates of MMP-9/TIMP-1 became lower with severity of illness. Conclusion Expression of MMP-9 in the PIH becomes significantly lower with severity of illness. There is no significant difference in TIMP-1 expression a-mong all the groups, which is also not correlated with PIH.%目的 探讨维吾尔族妊娠期高血压疾病(pregnancy induced hypertension,PIH)胎盘中MMP-9、TIMP-1的表达及与PIH的相关性.方法 收集新疆自治区人民医院产科2009年12月～2010年8月住院分娩的维吾尔族患者胎盘组织标本90例,其中子痫前期重度组30例,子痫前期轻度组30例,正常组30例.结果 (1)胎盘组织中MMP-9与TIMP-1分布一致,主要分布在滋养叶细胞、血管内皮细胞及绒毛间质细胞的胞质中.重度组胎盘组织中MMP-9阳性颗粒分布明显减少.MMP-9在三组比较中,差异有显著性;(2)重度组与正常组、轻度组两两相比差异均有显著性,随着PIH病情的加重,MMP-9的阳性表达逐渐降低;(3)TIMP-1在各组中的表达,差异无显著性;(4)重度组MMP-9/TIMP-1阳性表达比低于正常妊娠组及轻度组,而且随着病情的加重,二者阳性表达比逐渐变小.结论 (1)PIH患者胎盘组织中MMP-9的阳性表达水平随着PIH病情加重,明显减少;(2)PIH患者胎盘组织中TIMP-1在各组中变化不大,与PIH病情无明显相关性.
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