Objective To investigate the Helicobacter pylori (HP) infection in the clinical curative effect of peptic ulcer patients using proton pump inhibitor combined with Clostridium butyricum live bacteria treatment. Methods 112 cases of peptic ulcer patients with Helicobacter pylori infection were randomly divided into two groups, the study group used proton pump inhibitor combined with Clostridium butyricum lactobacillus tablets treatment, the control group only used proton pump inhibitor treatment, the clinical efifcacy of the two groups were compared. Results 1 months after treatment, symptom relief rate in study group was 98.21%, higher than 87.50%in control group, (χ2=4.846, P=0.028);ulcer healing rate in study group was 94.64%, superior than 75%in control group (χ2=8.391, P=0.004);HP eradication rate in study group was 89.29%, higher than 73.21%,in control group (χ2=4.747, P=0.029);adverse medication in the process were nausea, vomiting, loss of appetite, anorexia, dizziness, weakness, abdominal pain and distension, there were no signiifcant differences between two groups. Conclusion Proton pump inhibitor combined with Clostridium butyricum lactobacillus tablets has good curative effect and highly HP eradication rate on treatment with HP type peptic ulcer patients.%目的：探讨幽门螺杆菌（Helicobacter pylori，HP）感染的消化性溃疡患者采用质子泵抑制剂联合梭菌酪酸活菌片治疗的临床疗效。方法将112例幽门螺杆菌感染的消化性溃疡患者随机分为2组，研究组采用质子泵抑制剂联合梭菌酪酸活菌片治疗，对照组采用质子泵抑制剂治疗，比较2组的临床疗效。结果治疗后1个月，研究组症状缓解率98.21%，对照组87.50%，研究组显著优于对照组（χ2=4.846，P=0.028）；研究组溃疡愈合率94.64%，对照组75.00%，研究组显著优于对照组（χ2=8.391，P=0.004）；研究组HP清除率89.29%，对照组73.21%，研究组显著优于对照组（χ2=4.747，P=0.029）；服药过程中的不良反应分别为恶心、呕吐，食欲减退，纳差，头晕乏力，腹胀腹痛，2组差异无统计学意义，经对症治疗及综合护理后，不良反应得到缓解。结论 HP型消化性溃疡采用质子泵抑制剂联合梭菌酪酸活菌片治疗具有疗效好、HP根除率高等优点。
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