Objective To analyze the clinical effects of sevoflurane and propofol anesthesia on hemorrheology in elderly patients with colorectal cancer undergoing radical mastectomy.Methods 86 patients with colorectal cancer undergoing radical surgery in our hospital from March 2014 to December 2016 were selected and randomly divided into sevoflurane group and propofol group group with 43 cases in each group.Two groups of elderly patients were anesthetized before, 40 minutes after induction, 80 minutes after induction, 140 minutes after induction and 30 minutes after entering the anesthesia monitoring room 30 minutes to draw the neck 4 mL venous blood.Analysised of two groups of patients with hemorheology ( low cut blood viscosity, blood viscosity in the cut, high shear whole blood viscosity, plasma viscosity, erythrocyte deformation index, erythrocyte aggregation index) index.Results There was no significant difference in the difference of detection indexes between sevoflurane group and propofol group at each time point Comparison of sevoflurane group and propofol group in elderly patients, 40 min, 80 min after induction and 140 min after induction compared with those of pre-anesthesia low-cut whole blood viscosity, middle whole blood viscosity, high shear whole blood viscosity and plasma viscosity, the difference was statistically significant(P<0.05), erythrocyte deformation index and erythrocyte agglutination index were not significantly different between the two groups.The blood viscosity in the propofol group was significantly lower than that in the anesthesia group at 80 minutes after induction and 140 minutes after induction, the difference between the two groups was statistically significant (P<0.05).The whole blood viscosity of the sevoflurane group was significantly lower than that before anesthesia at 140 min, and the difference between the two groups was statistically significant (P<0.05).Conclusion From the point of view of hemorheology, sevoflurane and propofol anesthesia can be used in elderly patients with colorectal cancer radical operation.%目的 综合分析七氟醚与丙泊酚麻醉对结肠癌根治术老年患者血液流变学的临床影响.方法 选取2014年3月~2016年12月于浙江宁海县中医医院和杭州市第一人民医院收治的86例结肠癌根治术老年患者临床资料作为研究对象,按照入院顺序随机分为七氟醚组与丙泊酚组,每组各43例.2组老年患者分别在麻醉前、诱导后40 min、诱导后80 min、诱导后140 min以及进入麻醉后监测治疗室30 min抽取颈内4 mL静脉血.分析2组患者的血液流变学(低切全血黏度、中切全血黏度、高切全血黏度、血浆黏度、红细胞变形指数、红细胞聚集指数)指标.结果 七氟醚组与丙泊酚组老年患者各个时间点各个检测指标差异比较差异无统计学意义;七氟醚组与丙泊酚组老年患者组内比较,诱导后40 min、诱导后80 min、诱导后140 min与麻醉前低切全血黏度、中切全血黏度、高切全血黏度、血浆黏度比较,差异有统计学意义(P<0.05);红细胞变形指数、红细胞聚集指数的组内比较差异无统计学意义;丙泊酚组患者诱导后80 min、诱导后140 min中切全血黏度显著低于麻醉前,2组比较差异有统计学意义(P<0.05);七氟醚组患者诱导后140 min中切全血黏度显著低于麻醉前,2组比较差异有统计学意义(P<0.05).结论 从血液流变学角度来看,七氟醚与丙泊酚麻醉对结肠癌根治术老年患者均能够取得显著的应用价值.
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