免疫球蛋白G4相关性疾病与恶性肿瘤

摘要

IgG4-related disease ( IgG4-RD ) is an inflammatory condition characterized by intense lymphoplasmacytic infiltrates with increased IgG4-positive plasma cells. Recently, more and more studies reported the cases of co-occurrence of IgG4-RD and malignancy, which mainly included malignant lym-phoma developed on the background of IgG4-associated conditions and non-lymphoid tumor in patients with IgG4-RD. Several studies suggested that the patients with IgG4-RD are at high risk for cancer devel-opment. IgG4-RDs in different lesions predispose patients to specific tumors in these issues. Furthermore, malignancy may be associated with the subsequent development of IgG4-RD. The biological characteristics and functions of IgG4 and the immunological environment created by IgG4-RD are potential explanations for the co-occurrence of malignancy and IgG4-RD.%免疫球蛋白G4(immunoglobulin G4,IgG4)相关性疾病是一组具有特异性IgG4阳性浆细胞浸润表现的炎症性疾病.近年来对于IgG4相关性疾病并发恶性肿瘤的报道逐渐增多,主要有淋巴瘤和其他非淋巴性肿瘤.现阶段研究认为IgG4相关性疾病患者发生恶性肿瘤的风险增加,不同部位的IgG4相关性疾病诱导发生的恶性肿瘤类型具有一定的倾向性,而恶性肿瘤可能与IgG4相关性疾病的发生有关.IgG4的生物学特性和功能与IgG4相关性疾病的组织炎症表现可能帮助解释两种疾病之间的关系和发生机制.