CT冠状动脉成像对男性吸烟冠心病患者斑块量化特征的评价

摘要

Objective:To explore the difference of quantification of coronary artery plaques between smokers and nonsmokers using cardiac computed tomographic angiography (CCTA). Methods:A total of 354 patients including 121 smokers and 233 controls who underwent 64-slice CCTA and confirmed to have coronary plaques were studied. Plaque area,plaque volume,plaque burden,remodeling and ratio of thickness and length were compared between the two groups. Results:There was no difference for age,diabetes mellitus rate,BMI,blood pressure and blood lipid between the two groups. Smokers group had higher plaque area(median:7.03 mm2 vs. 5.81 mm2),plaque volume(28.31 mm3 vs. 13.67 mm3),plaque burden(49.52% vs. 35.34%),remodel-ing index(1.29 vs. 1.08) and ratio of thickness and length(0.35 vs. 0.25). Conclusion:Plaque area,plaque volume,plaque bur-den,remodeling and ratio of thickness and length measured on 64-slice CCTA are higher in smokers than those in nonsmokers.%目的：探讨吸烟者和非吸烟者64排CT冠状动脉成像（coronary CT angiography，CCTA）斑块量化特征的区别。方法：拟诊冠心病行64排CCTA检查且证实有斑块者354例，比较吸烟组121例和非吸烟组233例的冠状动脉粥样硬化斑块的最大横截面积、体积、斑块负荷、重构指数和厚度长度比。结果：2组年龄、体质量指数、糖尿病、高血压、高血脂发病率差异均无统计学意义（均P>0.05）。吸烟组斑块的最大横截面积、体积、斑块负荷、重构指数、厚度长度比分别为（7.03±3.51）mm2、（28.31±14.03）mm3、（49.52±16.07）%、1.29±0.36、0.35±0.13，均显著高于非吸烟组的（5.81±2.43）mm2、（13.67±5.00）mm3、（35.34±10.12）%、1.08±0.27、0.25±0.15（均P<0.05）。结论：64排CT能够有效测量斑块，吸烟患者的斑块体积、面积及斑块负荷、重构指数、厚度长度比均显著大于非吸烟患者。