中文版淋巴瘤患者生命质量测定量表的信效度评价

摘要

目的 检验中文版淋巴瘤患者生命质量测定量表(FACT-Lym)的信度和效度.方法 2016年3-8月采用便利抽样法,选取郑州大学第一附属医院和河南省肿瘤医院的淋巴瘤住院患者218例,采用中文版FACT-Lym进行调查.4周后随机选取50例患者进行重测.信度分析采用Cronbach's α系数及重测信度;效度分析采用内容效度、结构效度、效标关联效度、区分效度进行检验.结果 中文版FACT-Lym总量表Cronbach's α系数为0.836,重测信度为0.923 (P＜0.01).量表水平的专家内容效度指数(S-CCI)为0.91,条目水平的专家内容效度指数(I-CVI)为0.80～1.00.探索性因子分析(EFA)显示,KMO=0.749,Bartlett's球形检验x2=1 925.533,P＜0.001,提取4个公因子,累积方差贡献率为70.621％.以生活质量核心量表为校标,Spearman相关分析显示,中文版FACT-Lym总分与生活 质量核心量表的功能及整体生活质量维度均呈正相关(rs值为0.423 ～0.628,P＜0.01),与症状维度呈负相关(rs值 为-0.684 ～-0.251,P＜0.05).不同疾病状态、Ann Arbor分期、ECOG评分淋巴瘤患者中文版FACT-Lym得分比较,差异均有统计学意义(P＜0.05).结论 中文版FACT-Lym具有较好的信度和效度,可用于中国淋巴瘤患者生命质量的评估.%Objective To test the reliability and validity of Chinese version of Functional Assessment Cancer Therapy -Lymphoma (FACT-Lym).Methods From March to August 2016,a total of 218 lymphoma patients hospitalized in the First Affiliated Hospital of Zhengzhou University and Henan Province Cancer Hospital were enrolled by using convenience sampling method and investigated by using the Chinese version of FACT-Lym.Fifty patients were randomly selected for questionnaire retest four weeks later.Reliability analysis was performed using Cronbach's alpha coefficient and retest reliability.Validity analysis was tested by using content validity,construct validity,criterion related validity and discriminant validity.Results Cronbach's alpha coefficient of Chinese version of FACT-Lym total scale was 0.836,and retest reliability was 0.923 (P ＜ 0.01).The expert content validity index (S-CVI) of the scale was 0.91,and the expert content validity index (I-CVI) of each item was 0.80-1.00.Exploratory factor analysis (EFA) showed that KMO =0.749,Bartlett's spherical test x2 =1 925.533,P ＜ 0.001.Four common factors were extracted,the cumulative contribution rate was 70.621％.The quality of life core scale as calibration,Spearman correlation analysis showed that the Chinese version of the FACT-Lym total score and the function of quality of life core scale and overall quality of life dimensions were both positively correlated (rs =0.423-0.628,P ＜ 0.01),and negatively correlated with symptom dimensions (rs =-0.684--0.251,P ＜ 0.05).There were significant differences in Chinese version of FACT-Lym scores among different disease states,Ann Arbor staging,and ECOG score of lymphoma patients (P ＜ 0.05).Conclusion Chinese version of FACT-Lym has better reliability and validity,and can be used to evaluate the quality of life of Chinese lymphoma patients.