乳腺癌改良根治术后常规分割与大分割放疗毒性对比分析

摘要

目的：观察局部晚期乳腺癌改良根治术后常规分割放疗与大分割放疗的不良反应。方法：收治局部晚期乳腺癌患者66例，随机分为常规分割放射治疗组和大分割放射治疗组。大分割放射治疗组2.9 Gy/次，5次/周，总剂量43.5 Gy，常规分割治疗组2 Gy/次，5次/周，总剂量50 Gy。结果：中位随诊24个月，大分割放射治疗组和常规分割放射治疗组的急性及晚期损伤无明显差异。结论：大分割放射治疗缩短了治疗时间，可作为局部晚期乳腺癌改良根治术后常规放疗方法。%Objective:To observe the adverse reactions of conventional fractionation radiotherapy and larger fractionation radiotherapy after locally advanced breast cancer modified radical surgery.Methods:66 patients with locally advanced breast cancer were selected.They were randomly divided into the conventional fractionation radiotherapy group and the larger fractionation radiotherapy group.The larger fractionation radiotherapy group was given 2.9 Gy one time,5 times one week,the total dose of 43.5 Gy.The conventional fractionation radiotherapy group was given 2 Gy one time,5 times one week,the total dose of 50 Gy.Results:The median follow-up was 24 months.The larger fractionation radiotherapy group and the conventional fractionation radiotherapy group had not significantly different on the acute and late injury.Conclusion:Larger fractionation radiotherapy can shorten the treatment time,and it can be used as a conventional radiotherapy method for locally advanced breast cancer after modified radical surgery.