缬沙坦对兔颈动脉球囊损伤后血管内膜增生的影响观察与分析

摘要

目的：探讨缬沙坦对兔颈动脉球囊损伤后血管内膜增生的影响。方法：选择健康雄性大耳白兔42只，随机分为假手术组、对照组和缬沙坦组。以放射免疫方法对比3组的ET1、TXB2、6-keto-PCF1a，以制作弹力纤维染色、HE切片及PNCA免疫学组织分析对比3组的PNCA指数、内膜厚度、内膜截面积、管腔狭窄度。结果：对照组的ET1、TXB2最高，缬沙坦组次之，假手术组最低；缬沙坦组6-keto-PCF1a最高，假手术组次之，对照组最低；对照组的PNCA最高，缬沙坦组次之，假手术组最低；缬沙坦组的内膜厚度、内膜截面积、管腔狭窄度与PNCA均低于对照组(P＜0.05)。结论：缬沙坦对ET1、TXB2均有抑制作用，对于球囊损伤后平滑肌细胞的增殖有抑制作用。%Objective:To explore the effect of valsartan on vascular intimal hyperplasia after carotid artery balloon injury of rabbit. Methods:42 male rabbits were selected.They were randomly divided into the sham operation group.The control group and the valsartan group.We compared ET1,TXB2,6-keto-PCF1a of the three groups by the method of radioimmunoassay,and compared the PNCA index,intima-media thickness,intimal cross-sectional area,the degree of stenosis using elastic fiber staining,HE chip and PNCA immunohistochemical.Results:ET1,TXB2 of the control group was the highest;valsartan group was the second;sham operation group was the lowest.The 6-keto-PCF1a of valsartan group was the highest;the sham operation group was the second;the control group was the lowest.The control group of PNCA was the highest;the Valsartan group was the second;sham operation group was the lowest.In the valsartan group,endometrial thickness,intimal cross-sectional area,the degree of stenosis,PNCA were lower than those of the control group(P<0.05).Conclusion:Valsartan has inhibitory effect on ET1,TXB2,and smooth muscle cell proliferation after balloon injury.