我院2003-2011年3种抗癫痫药血药浓度监测回顾性分析

摘要

OBJECTIVE: To provide reference for rational use of antiepileptic drugs. METHODS: The results of blood concentration monitoring of 3 kinds of antiepileptic drugs (sodium valproate, carbamazepine, phenytoin sodium) in our hospital during 2003 — 2011 were analyzed retrospectively. RESULTS: The number of monitored cases for antiepileptic drugs had increased in our hospital year by year, with a total of 1 653 cases/times. Children patients accounted for 38.05% of all cases; more than half of drug concentrations monitored fell outside the normal concentration ranges, except for carbamazepine. CONCLUSION: Correct application of drug monitoring is of significance for the safety and effectiveness of epileptic treatment.%目的:为临床合理应用抗癫痫药提供参考.方法:回顾性分析我院2003-2011年3种抗癫痫药(丙戊酸钠、卡马西平、苯妥英钠)的血药浓度监测数据.结果:我院抗癫痫药血药浓度监测例数大体呈逐年上升趋势,共监测1 653例次；儿童进行血药浓度监测的例数占总例数的38.05％,除卡马西平组外,偏离有效浓度范围的比例均高于50％.结论:正确地应用治疗药物监测,对提高癫痫治疗的安全性和有效性具有重要指导意义.