Tigecycline is a new broad-spectrum antibiotic,which is the first glycyclines antibiotic used in clinic. Tigecycline is ac-tive against Gram-positive/negative bacteria and anaerobicbacteria, especially multidrug-resistant (MDR) pathogens. In this review, the literatures associated with tigecycline-induced coagulopathy published after 2005 were searched in Pubmed and the clinical charac-teristics as well as the research progress were summarized. The mechanism of tigecycline-induced coagulopathy was also explored. Cli-nicians should observe coagulation markers of patients during the treatment with tigecycline. If coagulation disorders or active bleeding occurs,tigecycline treatment should be stopped and symptomatic and supportive treatment should be given immediately.%替加环素(tigecycline)是一种新型广谱抗生素,为首个应用于临床的甘氨酰环素类抗生素,对革兰阳性球菌、革兰阴性杆菌和厌氧菌,特别是多药耐药(multidrug-resistant,MDR)致病菌有很强的抗菌活性.本文检索PubMed收录的相关文献,综述替加环素相关凝血功能障碍的临床特点和研究现状,探讨发生机制.建议用药期间临床医师应密切监测各项凝血指标,发生凝血功能障碍和活动性出血时应立即停药并给予积极的对症支持治疗.
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