丹参多酚酸盐联合苯扎贝特治疗缺血性心肌病53例及对炎性因子和心功能的影响

摘要

目的 探讨丹参多酚酸盐联合苯扎贝特对缺血性心肌病(ICM)患者炎性因子及心功能的影响.方法 选择2015年1月至2017年7月在医院接受治疗的ICM患者107例,根据随机数字表法将患者分为观察组53例及对照组54例.两组均给予常规基础治疗,对照组患者在此基础上予以苯扎贝特分散片(每次0.2 g,3次/日),观察组患者在对照组基础上加用注射用丹参多酚酸盐(200 mg,静脉滴注,1次/日),均治疗28 d.结果 观察组总有效率为96.23％,明显高于对照组的81.48％(P0.05);根据Spearman法分析相关性发现,107例患者的IL-6,MMP-9,MCP-1分别与LVESd和LVEDd均呈正相关(P 0. 05 ) . The correlation was analyzed according to the Spearman method, the result showed that IL-6, MMP-9 and MCP-1 of 107 patients were positively correlated with LVESd and LVEDd ( P < 0. 05 ) , and negatively correlated with LVEF ( P < 0. 05 ) . Conclusion Salvianolate combined with benzbette for treating ICM has good effect and safety, it can effectively improve the patients′ inflammatory factors and cardiac function, which is worthy of clinical promotion.