Objective To observe the clinical effect of 125I partides implatation combined with arteriovenous chemother-apy in treatment of locally advanced non-small sell lung cancer (NSCLC). Methods 45 patients with different patholog-ical types local advanced non-small sell lung cancer addmited in our hospital from June 2008 to June 2014 were ran-domly divided into group A,group B and group C,15 patients in each group.Group A were implanted with 125I partides under CT guidance puncture in 2 weeks after bronchial intra-arterial chemotherapy combined with intravenous systemic chemotherapy for 4 cycles;Group B were treated with bronchial intra-arterial chemotherapy combined with systemic vein chemotherapy for 4 cycles;Group C were treated with traditional systemic chemotherapy for 4 cycles.One treatment cycle were 21 days.All patients had finished 4 cycles treatment,then chest CT was reviewed after 1,3 and 6 months treatment.The curative effect,toxic and side effect was observed. Results All patients were received 4 cycles treatment. After 1,3 and 6 months treatment,the effective rate of group A was 100.0%,100.0%,86.7% respectively;group B was 73.3%,53.3%,40.0%respectively;group C was 46.7%,40.0%,33.3%respectively;the effective rate of group A was higher than that of group B and group C,the difference was significant (P<0.05). Conclusion The treatment of 125I partides im-plantation combined with arteriovenous chemotherapy for local advanced non-small sell lung cancer has significant cu-rative effect,is safe and reliable,is worth to be promoted in clinic.%目的：探讨125I粒子植入联合动静脉化疗治疗局部晚期非小细胞肺癌的临床效果。方法从本院2008年6月~2014年6月收治的不同病理类型局部晚期非小细胞肺癌患者中随机抽取45例患者为研究对象，分为A、B、C组，A组给予支气管动脉灌注化疗加静脉全身化疗4个周期后2周内在CT引导下穿刺植入放射性125I粒子进行治疗，B组给予支气管动脉灌注化疗加全身静脉化疗4个周期，C组采用传统方法予全身静脉化疗4个周期；3组均以21 d为1个周期，在完成4个周期治疗后于治疗后1、3、6个月时复查胸部CT以评价疗效，比较3组的治疗效果，观察毒副反应情况。结果所有患者均完成4个周期治疗。治疗后1、3、6个月A组的有效率分别为100.0%、100.0%、86.7%，B组的有效率分别为73.3%、53.3%、40.0%，C组的有效率分别为46.7%、40.0%、33.3%，A组的有效率明显高于B、C组，差异有统计学意义(P<0.05)。结论125I粒子植入联合动静脉化疗治疗局部晚期非小细胞肺癌，具有显著的治疗效果，安全可靠，值得临床大力推广应用。
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