Objective To discuss the clinical effects of hemoperfusion (HP) combined with plasma exchange (PE) in the treatment of severe organic phosphorus pesticide poisoning. Methods A total of 100 patients with severe organic phos-phorus pesticide poisoning who were admitted to our hospital from February 2012 to October 2014 were selected. Ac cording to patients' disease conditions, 50 patients were assigned to a treatment group (HP+HE), and another 50 patients were assigned to a control group (HP). Dosage of atropine and pralidoxime chloride, recovering time of CHE activity, average hospitalization days, coma time, complications and mortality rate between the two groups were compared. Re-sults Each observational index between the two groups was compared, and the results were significantly different (P<0.05). Effective rate in the treatment group was better than that in the control group, and the morality rate of 20.00%in the control group was significantly higher than that of 12.00% in the treatment group. Conclusion HP combined with PE is able to improve the curative effects of severe organic phosphorus pesticide poisoning significantly, reduce compli-cations and lower mortality rate.%目的：探讨血液灌流(HP)联合血浆置换(PE)治疗重度有机磷农药中毒的临床疗效。方法选取我院2012年2月~2014年10月EICU中100例重度有机磷农药中毒患者，根据患者病情选取其中50例作为治疗组(HP+PE)，选取另50例作为对照组(HP)，比较两组的阿托品及氯解磷定用量、CHE活力恢复时间、平均住院天数、昏迷时间、并发症、死亡率。结果两组之间各观察指标比较，均有显著性差异(P<0.05)，治疗组疗效优于对照组，对照组死亡率(20.00%)远高于治疗组死亡率的12.00%。结论血液灌流联合血浆置换能显著提高重度急性有机磷农药中毒疗效，减少并发症的发生，降低死亡率。
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