Objective To evaluate the effect and safety of dezocine and fentanyl combination intravenous injection for postoperative pain. Methods Totally 60 general anaesthesia patients of visual analogue scale ( ASA X grade I orII were randomly into two groups, dezocine combinded fentanyl group (D-F group) or fentanyl group (F group). There were 30 patients in each group. Loading dose was given 10 minutes before completion of the operation. D-F group were given dezocine 0. 1 mg/kg in intravenous injection, while F group were given fentainyl in a dose of 1 (xg/kg. Analgesia pump (2 ml/h) was connected after conscious awake. Prescription for analgesia pump was as follows. Dezocine 0.4 mg/kg + Fentanyl 8 μg/kg + droperidol 5 mg were added into 100 ml 0. 9% sodium chloride injection in D-F group. F group added fentanyl 16 μg/kg + droperidol 5 mg into 100 ml 0.9% sodium chloride injection. Effect and complication in two groups were observed and analyzed. Results There was no significant difference between two groups in analgesia effect (P > 0. 05 ). But total adverse reaction incidence ratio in D-F group was obviously lower than that in F group (P <0. 05) . Conclusion Dezocine and fentanyl combination intravenous injection for postoperative pain has many advantages such as satisfactory clinical effect, few adverse reaction incidences and reliable security.%目的 评价地佐辛复合芬太尼用于术后静脉镇痛的效果及安全性.方法 选择经全麻手术的ASA分级I～Ⅱ级的患者60例,按手术先后顺序分为地佐辛-芬太尼组及芬太尼组,每组30例,术毕前10 min给予负荷量,地佐辛-芬太尼组静脉注射地佐辛0.1 mg/kg,芬太尼组静脉注射芬太尼1μ/Kg,术后患者自控镇痛泵配方:地佐辛-芬太尼组为地佐辛0.4 mg/kg+芬太尼8μg/kg+氟哌利多5mg+生理盐水至100 ml;芬太尼组为芬太尼16μg/kg+氟哌利多5 mg+生理盐水至100 ml.对2组镇痛效果和并发症进行观察并记录.结果 地佐辛-芬太尼组术后24、48 h镇痛药消耗量和视觉模拟评分(VAS)均低于芬太术后48 h的VAS差异有统计学意义[芬太尼组(2.83±1.42)分,地佐辛-芬太尼组(1.94±1.08)分,P<0.05].芬太尼组术后24 h镇静评分,2分3例;术后48 h镇静评分,2分4例.地佐辛.芬太尼组术后24 h镇静评分,2分13例;48 h镇静评分,2分15例,3分1例.地佐辛-芬太尼组术后24、48 h镇静评分2分及以上的患者数多于芬太尼组,差异有统计学意义(P<0.05).芬太尼组术后24 h呕吐评分,1分5例;48 h,1分8例;地佐辛-芬太尼组术后24 h,1分3例;48 h,1分1例.地佐辛-芬太尼组呕吐评分1分及以上的患者例数少于芬太尼组,差异有统计学意义(P<0.05).结论 地佐辛复合芬太尼用于术后静脉镇痛的镇痛效果具有使用剂量小、不良反应较轻等优点.
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