灯盏细辛注射液的抗氧化作用

摘要

目的 探讨灯盏细辛注射液的抗氧化作用 .方法 对比50例门诊患者(存在胸闷、胸痛、头晕、肢体麻木、言语謇涩、中风偏瘫等症状)接受灯盏细辛注射液治疗前后血浆中的丙二醛,髓过氧化物酶和还原型谷胱甘肽浓度的差异.结果 患者静脉滴注灯盏细辛注射液治疗90 min后,血浆丙二醛、髓过氧化物酶明显降低[(1.2 ± 0.3)μmol/L 比(1.5 ± 0.3)μmol/L,P=0.023 5;(200± 48) μg/L 比(223 ±43) μg/L,P=0.013 2],还原型谷胱甘肽浓度升高[(4.3 ± 2.7) μmol/L 比(3.4 ± 1.7) μmol/L,P=0.048 9].结论 灯盏细辛注射液可抑制体内氧自由基,升高还原物质含量,发挥抗氧化作用.%Objective To discuss the antioxidant effect of Dengzhanxinxi injection.Methods This study included 50 outpatients who had chest pain,dizziness,numbness,speech Jian astringent,stroke,paralysis and other symptoms before having fleabane injection treatment.Plasma malondialdehyde,medullary peroxidase (MPO)and reduced glutathione (GSH) concentration were detected.Results After treatment of Dengzhanxinxi injection,plasma malondialdehyde decreased [(1.2 ± 0.3) μmol/L vs (1.5 ± 0.3) μmol/L,P =0.023 5] ; MPO concentration decreased [(200 ±48)μg/L vs (223 ±43)μg/L,P =0.013 2]; the GSH concentrationicreased[(4.3 ±2.7)μmol/L vs (3.4 ±1.7)μmol/L,P=0.048 9].Conclusion Dengzhanxinxi can inhibit oxygen free radicals.