目的:探讨无抽搐电休克治疗(MECT)对精神分裂症患者症状和执行功能的影响.方法:将132例精神分裂症患者分为研究组(MECT合并非典型药物治疗)68例和对照组(单纯非典型药物治疗)64例.分别在入组前、治疗3周及6周后分别进行阳性与阴性症状量表(PANSS)评定、威斯康星卡片分类任务(WCST)、Stroop测验.结果:治疗3周后两组PANSS总分较治疗前均有显著下降(均P<0.01),WCST中的总应答数、完成分类数、正确数、持续错误数及Stroop测验color word(CW)总反应时间均较治疗前明显改善(P<0.05或P<0.01),且研究组比对照组在PANSS、WCST方面改善更为明显(P<0.05或P<0.01).治疗6周后两组的PANSS总分较治疗前均有显著改善(均P<0.01),WCST中的总应答数、完成分类数、正确数分值均较治疗前改善(P<0.05或<0.01),但两组之间在PANSS、WCST分值及Stroop测验各分值方面比较,差异无统计学意义(P>0.05).结论:合并MECT治疗能快速改善精神分裂症患者的执行功能.%Objective: To explore MECT effect in syndrome and executive function in patients with schizophrenia. Methods: 132 patients with schizophrenia were divided to study group (68 cases) and control group (64 cases). Both groups were given the same kind of antipsychotic drug. Meanwhile, MECT was added in study group. Every patients were detected by assessment including PANSS scale, Wisconsin Card Sorting Test (WCST) and Stroop test before treatment 3 weeks and 6 weeks after treatment. Results: 3 weeks after treatment, PANSS scores were lower than those before treatment significantly (all P<0.01). Total response number, correct number, continual wrong number in WCST of both groups were better than those before treatment significantly (P<0.05 or P<0.01) as well as CW total response time in Stroop test. Completing sorting number was better than that before treatment significantly (P<0.01). Additionally, PANSS and WCST scores in study group were better than those in control group (P<0.05 or P<0.01). 6 weeks after treatment, PANSS scores were better than those before treatment significantly (all P<0.01). Total response number and correct number in WCST of both groups were better than those before treatment significantly (P<0.05 or P<0.01). Also, Completing sorting number was better than that before treatment significantly(P<0.01). But there was no significant difference of PANSS, WCST and stroop test score between the two groups (P>0.05). Conclusion: Combination of MECT can cure positive syndrome and improve executive function quickly.
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