乌司他丁对急性创伤患者血清肿瘤坏死因子、白细胞介素-8、白细胞介素-10浓度的影响

摘要

Objective To study the correlation between Ulinastatin and serum levels of TNF-a, IL-8 and 1L-10 in patients with acute wounds. Methods 46 patients with acute wounds were randomly divided into two groups. Patients in A group was treated with conventional anti-inflammatory treatment, while patients in group B was treated with Ulinastatin on the basis of the conventional treatment. Peripheral blood were collected before treatment and after treatment on the one, three and five day. Serum levels of TNF-α, IL-8 and IL-10 were determined by El,ISA. 20 healthy persons served as control. Results Serum level TNF-α and IL-8 in A and B two groups of patients were significantly higher than group C (P < 0.05j. Serum level of TNF-a and IL-8 level before treatment in A and B groups were not significantly (P > 0.05). Serum level of TNF-a and IL-8 in group B on day three and five were lower than in group A (P < 0.05), and serum level of 1L-10 in the group B were higher than group A (P < 0.05). Conclusion Ulinastatin can inhibit release of TNF-α、IL-8 on serum in trauma patients, and promote release of anti-inflammatory cytokine IL-10, can effectively reduce inflammatory response of the trauma patients.%目的 观察乌司他丁对急性创伤患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)浓度的影响.方法 46例急性创伤患者随机分成A、B两组,A组给予常规清创、抗感染等处理,B组在常规清创、抗感染等处理的基础上,加用乌司他丁治疗.分别在治疗前及治疗后第1、3、5天取外周静脉血,采用ELISA法检测血清中的TNF-α、IL-8、IL-10水平.同时将20例健康体检者作为对照C组.结果 治疗前A、B两组血清TNF-α、IL-8浓度比较差异无统计学意义(P>0.05),治疗后第3、5天B组血清中TNF-α、IL-8浓度明显低于A组(均P<0.05),且B组血清中IL-10浓度第3、5天明显高于A组(均P<0.05).结论 乌司他丁能抑制创伤患者血清中TNF-α、IL-8的释放,促进抗炎因子IL-10的释放,从而有效降低创伤患者的炎症反应.