奥曲肽联合乌司他丁对老年急性胰腺炎患者血清肿瘤坏死因子α及白细胞介素-2水平的影响分析

摘要

Objective:To analyse the octreotide combined ulinastatin on elderly patients with acute pancreatitis serum tumor necrosis factor alpha and interleukin 2 levels, for clinical reference. Methods:From August 2010 to July 2013 elderly patients with acute pancreatitis,65 cases included in this study,both on the basis of conventional treatment accepted Mr Octreotide combined ulinastatin treatment.Compared before and after treatment in patients with serum tumor necrosis factor alpha and interleukin-2levels of change. Results:Compared with before treatment,we found that after treatment in patients with serum tumor necrosis factor alpha and interleukin-2 levels have declined,after statistical analysis that the significant dif erence (p<0.05). Conclusion:In the treatment of senile acute pancreatitis by Mr Octreotide combined ulinastatin treatment,can ef ectively reduce the level of serum tumor necrosis factor alpha and interleukin 2,by blocking the release of inflammatory mediators in serum and play the role of pancreas injury,control the condition.%目的：分析奥曲肽联合乌司他丁对老年急性胰腺炎患者血清肿瘤坏死因子α及白细胞介素-2水平的影响，以供临床参考。方法将我院2010年8月~2013年7月收治的老年急性胰腺炎患者65例纳入本研究，均在常规治疗基础上接受奥曲肽联合乌司他丁治疗。对比治疗前后患者血清肿瘤坏死因子α及白细胞介素-2水平的变化。结果与治疗前对比，我们发现患者治疗后血清肿瘤坏死因子α及白细胞介素-2水平均有所下降，差异经统计学分析后认为有意义（P＜0.05）。结论在老年急性胰腺炎的治疗中采用奥曲肽联合乌司他丁治疗，可有效降低血清肿瘤坏死因子α及白细胞介素-2水平，通过阻断血清中炎症介质的释放而发挥减轻胰腺损伤、控制病情的作用。