生长抑素联合肠梗阻导管治疗粘连性肠梗阻的临床研究

摘要

目的 探讨生长抑素联合肠梗阻导管治疗粘连性肠梗阻的临床疗效.方法 选取首都医科大学潞河数学医院2010年1月～2012年8月收治的粘连性肠梗阻患者107例,随机分为四组,28例患者采用鼻胃管治疗为对照Ⅰ组,26例患者采用肠梗阻导管治疗为对照Ⅱ组,26例患者采用生长抑索联合鼻胃管治疗为对照Ⅲ组,27例患者采用生长抑素联合肠梗阻导管治疗为观察组.比较四组患者治疗后的临床指标改善情况、中转手术情况、临床疗效、患者满意度.结果 在腹胀痛缓解时间和恢复排气时间上,对照Ⅰ组、对照Ⅱ组、对照Ⅲ组、观察组依次呈现出了明显的递减趋势；在胃肠减压量上,对照Ⅱ组、观察组、对照Ⅰ组、对照Ⅲ组依次呈现出了明显的递减趋势,组间差异均有统计学意义(P＜ 0.05).在中转手术情况上,对照Ⅰ组、对照Ⅱ组、对照Ⅲ组、观察组依次呈现出了递减趋势(P=0.032),观察组的中转手术率明显低于对照Ⅰ组和对照Ⅱ组；在患者满意度上,对照Ⅰ组、对照Ⅱ组、对照Ⅲ组、观察组依次呈现出了递增趋势(P=0.004),观察组和对照Ⅲ组患者满意度明显高于对照Ⅰ组；在临床疗效上,对照Ⅰ组、对照Ⅱ组、对照Ⅲ组、观察组依次呈现出了递增趋势(P=0.032),观察组的总有效率明显高于对照Ⅰ组和对照Ⅱ组,差异均有统计学意义(P＜0.05).结论 生长抑素联合肠梗阻导管治疗粘连性肠梗阻具有显著的临床疗效,可以明显改善患者的临床指征,提高保守治疗的成功率,值得临床推广使用.%Objective To investigate the clinical effect of somatostatin and intestinal obstruction catheter in the treatment for adhesive intestinal obstruction.Methods 107 patients with adhesive intestinal obstruction were selected in Luhe Teaching Hospital, Capital Medical University from January 2011 to August 2012, who were randomly divided into 4 groups.28 patients used nasogastric tube in the treatment as the control Ⅰ group.26 patients used intestinal obstruction catheter in the treatment as the control Ⅱ group.26 patients used somatostatin and nasogastric tube in the treatment as the control Ⅲ group.27 patients used somatostatin and intestinal obstruction catheter in the treatment as the observation group.Clinical indicator improving situation, transshipment operation situation, clinical efficacy, patient satisfaction were compared between 4 groups after the treatment.Results In the bloating pain relief time and recovery exhaust time, the control Ⅰ group, the control Ⅱ group, the control Ⅲ group, the observation group showed significant decreasing trend.In the gastrointestinal decompression amount, the control Ⅱ group, the observation group, the control Ⅰ group, the control Ⅲ group showed significant decreasing trend.The differences were statistically significant between each other (P < 0.05).In the transit operation situation, the control Ⅰ group, the control Ⅱ group, the control Ⅲ group, the observation group showed decreasing trend (P - 0.032).The transit operation rate in the observation group was significantly lower than the control Ⅰ group and control Ⅱ group.In the patient satisfaction, the control Ⅰ group, the control Ⅱ group, the control Ⅲ group, the observation group showed increasing trend (P = 0.004).Patients satisfaction in the observation group and control Ⅲ group were significantly higher than the control Ⅰ group.In the curative effect, the control Ⅰ group, the control Ⅱ group, the control Ⅲ group, the observation group showed increasing trend (P= 0.032).Total efficiency in the observation group was significantly higher than the control Ⅰ group and control Ⅱ group.The difference was statistical significance (P < 0.05).Conclusion Somatostatin and intestinal obstruction catheter in the treatment for adhesive intestinal obstruction have remarkable clinical effect, which can significantly improve clinical indications of patients.That can improve the success rate of conservative treatment.That is worthy of clinical use.