复发性流产患者血清维生素D水平与自身免疫抗体、r淋巴细胞亚群的关系研究

摘要

目的 探讨复发性流产(RSA)患者血清维生素D水平与自身免疫抗体、淋巴细胞亚群的关系.方法回顾性分析RSA患者125例,根据血清25羟维生素D[25(OH)D]水平,分为25(OH)D正常水平组50例、25(OH)D低水平组75例,分析两组自身免疫抗体阳性率及淋巴细胞亚群水平.结果25(OH)D低水平组抗心磷脂抗体(ACA)、抗核抗体(ANA)的阳性率及甲状腺过氧化物酶(TPO)抗体阳性率均高于25(OH)D正常水平组,差异有统计学意义(P<0.05);25(OH)D低水平组外周血CD3+CD4+、CD4+/CD8+、CD19+及CD56+百分率均高于25(OH)D正常水平组,差异有统计学意义(P<0.05).结论RSA患者中维生素D缺乏的比例较高,维生素D缺乏的RSA患者ACA、ANA及TPO抗体阳性率较高,RSA维生素D水平与CD4+T细胞、B细胞及NK细胞免疫平衡有关.%Objective To investigate the relationship between serum vitamin D level and autoantibodies or lymphocyte subsets in patients with recurrent spontaneous abortion (RSA). Methods A total of 125 patients with RSA were included in a retrospective analysis. According to the serum levels of 25-hydroxy vitamin D [25-(OH)-D], the patients were divided into [25-(OH)-D] normal group including 50 cases and [25-(OH)-D] low level group including 75 cases. The positive rate of autoantibodies and the level of lymphocyte subsets in the two groups were analyzed. Results Compared with the [25-(OH)-D] normal group, the positive rates of anticardiolipin antibody (ACA), antinuclear antibody (ANA) and thyroid peroxidase (TPO) antibody were higher in the [25-(OH)-D] low level group, the difference was statistically significant ( P<0.05); the percentages of (CD3+/CD4+) T, CD4+/CD8+, CD19+ B cells and CD56+ natural killer (NK) cells were higher in the [25-(OH)-D] low level group, the difference was statistically significant ( P<0.05). Conclusions The rate of vitamin D deficiency is higher in women with RSA. The positive rates of ACA, ANA and TPO are higher in RSA women with vitamin D deficiency. The vitamin D level in women with RSA is related to CD4+T cells, B lymphocytes and the balance of NK cells.