Objective To explore the correlation of Cys-C and IL-8, and analyze its application value in bronchial asthma. Methods Totally 157 patients with bronchial asthma received treatment in our hospital, and discharged from our hospital when their disease state was stable. According to the patient's condition at admission, they were divided into 4 groups;there were 43 cases in remission stage in group A, 42 cases in mild acute attack stage in group B, 39 cases in moderate acute attack stage in group C and 33 cases in severe acute attack stage in group D. And 110 healthy people were enrolled into control group. The content of serum Cys-C and IL-8 was measured, sputum cells were accounted and sorted, and lung function was tested in each group. Results The Cys-C level of the control group, group A, group B, group C and group D was (275.69 ± 32.90) pg/ml, (385.83 ± 49.84) pg/ml, (537.83 ±53.29) pg/ml, (794.26±66.83) pg/ml and (993.78±89.24) pg/ml respectively. The plasma Cys-C level of the groups B, C and D was higher than that of the group A and the control group ( < 0.05); and the plasma Cys-C level of the group D was higher than that of the groups B and C ( < 0.05). The serum IL-8 level of the groups B, C and D was (499.63±75.84) pg/ml, (586.73 ± 72.38) pg/ml and (625.92 ± 98.43) pg/ml respectively, which was higher than (425.38 ± 84.96) pg/mL of the group A and (283.6 ± 49.35) pg/ml of the control group, the differences were statistically significant ( < 0.05); but there was no statistical difference between the group A and the control group ( > 0.05). Pearson correlation analysis showed that Cys-C level of the patients in acute attack period was in negative correlations with FEV1 ( =-0.585, =0.008), PEF%expectation ( =-0.493, =0.019) and FEV1/FVC ( = -0.583, = 0.007), while in positive correlations with IL-8 ( = 0.637, = 0.003), total number of induced sputum cells ( = 0.425, = 0.011) and percentage of eosinophiles ( = 0.485, = 0.019). Conclusions With the development of bronchial asthma, the serum levels of Cys-C and IL-8 significantly increase, and Cys-C is associated with IL-8, which can be used as an indicator of asthma control.%目的：探讨胱抑素C（Cys- C）与白细胞介素8（IL-8）的相关性，并分析其在支气管哮喘中的应用价值。方法157例支气管哮喘患者在南华大学附属第二医院接受治疗，病情稳定后出院，根据患者入院时病情将其分为哮喘缓解期（A组）43例、轻度急性发作期（B组）42例、中度急性发作期（C组）39例和重度急性发作期（D组）33例以及110例健康者为对照组。测定上述各组患者血清Cys- C及IL-8含量，同时对各组痰细胞进行分类并计数，并检测各组肺功能。结果对照组、A组、B组、C组、D组Cys- C水平分别为（275.69±32.90）、（385.83±49.84）、（537.83±53.29）、（794.26±66.83）及（993.78±89.24）pg/ml；B、C、D组患者血浆Cys- C水平高于A组及对照组（<0.05），而D组患者高于B、C组（<0.05）。B、C、D组血清IL-8水平分别为（499.63±75.84）、（586.73±72.38）和（625.92±98.43）pg/ml，高于 A 组（425.38±84.96）pg/mL 及对照组（283.6±49.35） pg/ml，差异有统计学意义（<0.05），A组与对照组比较差异无统计学意义（>0.05）。皮尔森相关分析表明，急性发作期患者Cys- C水平与FEV1（=-0.585，=0.008）、PEF％预计值（=-0.493，=0.019）、FEV1/FVC（=-0.583，=0.007）呈负相关，与IL-8（=0.637，=0.003）、诱导痰细胞总数（=0.425，=0.011）、嗜酸粒细胞百分比（=0.485，=0.019）呈正相关。结论随着支气管哮喘患者病情的发展，其血清浆中Cys- C和血清IL-8水平均升高，且Cys- C与IL-8具有相关性，可作为哮喘控制水平的评价指标。
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