The levels of serum cystatin C, brain natriuretic peptide in traumatic patients and correlation analysis with traumatic severity

摘要

Objective: To observe the levels of serum cystatin C (Cys C), brain natriuretic peptide (BNP)in traumatic patients and correlation analysis with traumatic severity. Methods: 120 emergencytraumatic patients in emergency department of our hospital were rolled from December 2015to December 2016, who were divided into minor trauma group (n=41), severe trauma group(n=43) and critical trauma group (n=36) according to the injury severity score (ISS). The levelsof serum Cys C, BNP of the patients in the 3 groups were detected on 0 h, 24 h, 3 d and 7 dafter admission respectively. Pearson correlation analysis of the levels of serum Cys C, BNPand ISS. Results: There were no significant differences in the levels of serum Cys C, BNP on0 hours between the three groups; There were no significant differences in the levels of serumCys C, BNP on 0 h, 24 h, 3 d and 7 d in minor trauma group; The levels of serum Cys C, BNPon 24 h, 3 d and 7 d were all higher than those of 0 h in severe trauma group, and the levels ofserum Cys C on 3 d and 7 d were both higher than those of 24 h; The levels of serum Cys C,BNP on 24 h, 3 d and 7 d were all higher than those of 0 h in critical trauma group, the levelsof serum Cys C, BNP on 3 d and 7 d were both higher than those of 24 h, and the levels ofserum Cys C on 7 d were higher than those of 3 d ; The levels of serum Cys C, BNP in severetrauma and critical trauma groups were significantly higher compared with minor trauma groupon 24 h, 3 d and 7 d. Pearson correlation analysis, the level of serum Cys C were positivelycorrelated with ISS, the level of serum BNP were positively correlated with ISS. Conclusion:Different levels of traumatic patients had different levels of serum Cys C, BNP increased atdifferent times. Pearson correlation analysis showed that the levels of serum Cys C, BNP wereboth positively correlated with traumatic severity, which suggested that the levels of serumCys C, BNP may be important indicators of traumatic severity and could provide importantreference value for clinical evaluation of traumatic severity.