慢性乙肝患者HBV-DNA、HBeAg及肝功能的关系分析

摘要

目的：探讨HbeAg阴性或阳性的慢性乙肝患者（CHB）的HBV-DNA载量及其与肝功能某些指标的关系。方法对我院86例慢性乙肝患者临床资料进行回顾性分析，以ELISA检测技术检测HBV标志物，并采用荧光PCR对HBV-DNA进行定量分析。采用全自动生化分析仪对肝功能进行指标测定。结果 HbeAg阳性乙肝患者的HBV-DNA阳性率达到94.1%，显著高于HbeAg阴性患者；HbeAg阳性患者的AST、ALT高于阴性患者，PA低于阴性患者，差异均有统计学意义。结论慢性乙肝患者的HBV-DNA与HBeAg具有正相关性，患者肝功能损害严重，并发症情况复杂。%Objective To investigate the relationship among HbeAg (negative or positive),HBV-DNA load and indicators of liver function of CHB patients. Methods The clinical data of 86 cases of chronic hepatitis B patients were retrospectively analyzed,ELISA detection technology was used to detect HBV markers,and PCR for HBV-DNA fluorescence quantitative analysis. Using automatic biochemical analyzer on liver function parameters was measured. Results The positive rate of HBV-DNA inpatients of HbeAg positive is 94.1%, significantly higher than patients of HbeAg negative,AST and ALT of HbeAg positive patients were higher than negative patients, but PA was less than negative ones. Conclusion The HBV-DNA and HbeAg of CHB patients show a good consistency; Liver function in patients with CHB was seriously damaged,and the complications were complex.