目的：观察腹部手术使用帕瑞昔布钠或地佐辛超前镇痛的效果和安全性。方法根据使用超前镇痛药物不同将105例择期行腹部手术患者进行分组，分别在麻醉诱导前和手术结束前给予静脉滴注帕瑞昔布钠（帕瑞昔布钠组）、地佐辛（地佐辛组），采用视觉模拟评分（VAS）评价患者镇痛效果。结果地佐辛组在术后30 min末、4 h末疼痛程度（VAS评分）低于帕瑞昔布钠组，P＜0.05；帕瑞昔布钠组不良事件发生率3.85%与地佐辛组3.77%比较，P＞0.05。结论帕瑞昔布钠和地佐辛组均能够有效降低术后疼痛，但后者在早期镇痛方面优于前者，值得临床对作用机制和镇痛效果继续探讨。%Objective To observe the abdominal surgery parecoxib sodium or dezocine preemptive analgesia efficacy and safety. Methods According to different use of analgesic drugs lead to 105 cases of patients undergoing elective abdominal surgery group, respectively, before the induction of anesthesia before the end of surgery and intravenous infusion of parecoxib sodium (parecoxib sodium group), dezocine (dezocine group), using a visual analog scale (VAS) evaluate the analgesic effect in patients. Results Dezocine group after 30 min late, 4 h end of pain (VAS score) was significantly lower than parecoxib sodium group, P<0.05, incidence of adverse events parecoxib sodium group 3.85%and Dezocine comparison group 3.77%, P>0.05. Conclusion Parecoxib sodium and Dezocine group were able to reduce postoperative pain, but the latter than the former in early analgesia, is worthy of the mechanism of action and to continue to explore the analgesic effect.
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