sedative or anesthetic delivery host / guest composition, anesthetic or sedative composition, anesthetic or sedation composition, method of induction or maintenance by intermittent bolus administration or infusion, anesthesia or sedation in an individual, 5 use of neuroactive steroid anesthetic and clodextrin or a modified form thereof in the manufacture of a medicament for inducing anesthesia in an individual and method of inducing or maintaining by intermittent bolus administration or infusion, sedation in a human subject.

摘要

The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.