利鲁唑在神经保护、镇痛及抗抑郁领域的研究进展

摘要

Riluzole is a benzothiazole derivative,which has a wide range of pharmacology action.The current research is focused on the mechanism about glutamate inhibition,sodium and calcium channel inhibitions,neuro protection and its application research on analgesia,anti-depressant,anti-anxiety and so on.In this paper,the research progress of riluzole on neuroprotection,analgesia and anti-depressant applications in recent three years is summarized.%利鲁唑是苯并噻唑类衍生物,具有非常广泛的药理学作用.利鲁唑对谷氨酸的抑制、对钠通道和钙通道的抑制以及神经保护等作用机制是目前的研究热点,利鲁唑在镇痛、抗抑郁、抗焦虑等方面的应用研究也引起了广泛关注.综述了近3年来利鲁唑在神经保护、镇痛及抗抑郁领域的研究进展.