克拉霉素与百里酚蓝荷移配合物的光度分析研究

摘要

ase on the charge-transfer reaction between clarithromycin and thymol blue in ethanol solution, a spectrophotometric method was established for the determination of clarithromycin in preparations. The experimental results show that the composition ratio of the complex is 1 : l.the apparent molar absorptivity is 1.66×104 L · mol-1 · cm-1 at maximum absorption wavelength 442nm,and the linear range of the determination is 8. 278-57.59mg/L%利用克拉霉素与百里酚蓝在乙醇介质发生荷移反应,建立了荷移分光光度法测定克拉霉素含量的方法.结果表明,荷移反应生成1∶1型配合物,最大吸收波长为442 nm,表观摩尔吸光系数为ε=1.66×104L·mol-1·cm-1,克拉霉素测定线性范围为8.278～57.59 mg/L.