首页> 中文期刊> 《高等学校化学学报》 >细胞相容性聚氨酯的合成及其细胞相容性研究

细胞相容性聚氨酯的合成及其细胞相容性研究

         

摘要

在紫外光和过氧化氢的共同作用下, 过氧化氢基团被引人到聚氨酯膜(PU)表面. 将丙烯酸羟乙酯(HEA)吸附于氧化后的PU膜表面, 在紫外光下实现了膜表面的接枝, 并考察了接枝膜的表面性能. 人体脐带静脉内皮细胞粘附和生长的研究表明, HEA接枝后的PU表面细胞粘附率显著提高, 细胞的生长速率加快, 增值率提高.%Cell compatible polyurethane(PU) was obtained by surface photo-grafting of 2-hydroxyethyl acrylate(HEA) onto PU membrane surface. Hydroperoxide groups were introduced onto PU membrane surface by photo-oxidization, then the oxidized membrane, immersed previously in monomer solution, was irradiated under UV light. The grafted copolymers were characterized by ATR-FTIR spectra, element spectroscopy for chemical analysis(ESCA) and static water contact angle. The results showed that grafting was confined within the surface layer. Cell compatible study revealed that the attachment and growth of human umbilical vein endothelial(HUVE) cells were improved after HEA grafting. Cells grew faster on the surface with higher oxygen content.

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