Surface modifier, production manner and bone way of cell compatibility material and cell compatibility material transplantation ones and bone way production manner of transplantation ones.

摘要

PPROBLEM TO BE SOLVED: To provide a cytophilic material which ensures both biological functions and mechanical properties near to those of bone tissues in living bodies, and to simply provide a bone-like transplant using the cytophilic material. PSOLUTION: An amide derivative represented by the general formula: A-(Sp)-B or B-(Sp)-A-(Sp)-B (A is an amide bond-containing portion having a specific NRSP1/SPCO structure which may form a ring capable of binding to Sp or B; Sp is a spacer portion which may be present or absent; B is at least one substrate-binding portion selected from the group consisting of specific structure silyl groups capable of binding to Sp or A and also capable of binding to polar group-containing substrates, and phosphate esters and phosphate ester salts having specific structures). The surface-modifying agent comprising the amide derivative. The cytophilic material obtained by treating the surface of the polar group-having substrate with the surface-modifying agent. PCOPYRIGHT: (C)2006,JPO&NCIPI