聚多巴胺-阿霉素纳米颗粒对癌细胞的化疗-光热治疗协同作用

摘要

Polydopamine( PDA) nanoparticles were prepared with ethanol and ammonia in water, which per-formed an excellent light-heat energy conversion ability. An anti-cancer medicine, doxorubicin(Dox), was loaded on the surface of the polydopamine nanoparticles efficiently through π-π stacking and covalent bond, and then the doxorubicin loaded polydopamine ( PDA-Dox ) nanoparticles were prepared. The drug delivery property of the materials was studied. As a result, the drug release behavior could be controlled by the pH val-ue of the environment, which was improved in acidic condition. When the PDA-Dox nanoparticles were ex-posed to the laser irradiation, the cancer cell, HeLa, could be killed efficiently by the materials through the chemo-photothermal synergistic therapy. Combined with the laser irradition, the nanomaterial could kill the cancer cell efficiently with the synergistic therapy between the phototherpy and chemotherapy in vitro.%通过在水相中加入乙醇和氨水，将单分子多巴胺聚合成具有良好光热转换能力的聚多巴胺纳米颗粒( PDA)，并利用π-π作用与共价键作用，将抗癌药物阿霉素( Dox)负载到聚多巴胺纳米颗粒的表面，制备了聚多巴胺纳米颗粒负载阿霉素( PDA-Dox)，研究了PDA-Dox的药物缓释性能。结果发现， PDA-Dox能够在酸性环境下增加药物释放。细胞实验显示， PDA-Dox配合激光照射，能够通过化疗和光热治疗高效地杀死癌细胞。