CuI促进下乙羧氟草醚的合成

摘要

Fluoroglycofen-ethyl was synthesized from starting materials m-hydroxybenzoie acid and 3-Chloro-4-iodobenzotrifluoride via four steps including salification,etherification,nitration, condensation etc. Diaryl ether synthesis can be performed at 120℃ in good to excellent yields under the assistance of CuI. The structure of target compound was confirmed by IR,1H-NMR and MS,Total yield was 72%.%以间羟基苯甲酸和3-氯-4-碘三氟甲苯为原料,在CuI促进下,温度在120℃时高收率地合成了二芳基醚化合物,经过成盐、醚化、硝化、缩合4步反应得到乙羧氟草醚,所得产物化学结构经红外光谱、核磁共振谱及质谱等确证.乙羧氟草醚的合成总收率为72％.