天然抗氧化剂紫檀芪的合成

摘要

PterostiIbene was synthesized from 3 ,5-dimethoxy benzoic acid and P-hydroxybenzaIdehyde through reduction,chIorination,protecting hydroxybenzene using 2,3-dihydropyran,Witting-Horner and deprotection,the totaI yieId is 70. 7%. The structure of intermediates and target compounds were charac-terized by IR,MS and 1 H NMR. The production technoIogy had the advantages of brief reaction steps and Iow cost but high yieId,and it has great promising for industriaI appIication.%以3，5-二甲氧基苯甲酸为原料，经还原、氯代、Arbuzov重排反应，得到中间体3，5-二甲氧基苄基磷酸酯，与二氢吡喃（ DHP）保护的对羟基苯甲醛经过Witting-Horner缩合反应及脱保护合成天然抗氧化剂紫檀芪，总收率70.7％。中间体和目标化合物的结构用IR、MS和1 H NMR进行了表征。此合成工艺原料价廉易得、合成步骤少、产率高，具有较好的工业应用前景。