激素联合高压氧治疗一氧化碳中毒迟发性脑病的疗效观察

摘要

Objective To study the effect of the treatment for delayed encephalopathy after acute carbon monoxide poisoning( DEAC-MP) by combining hormone with hyperbaric oxygen. Methods Eighty cases of patients diagnosed as the DEACMP from from June 2010 to January 2014 in Chinese People's Liberation Army 105th hospital were randomly divided into observation group and control group(n=40). The control group used the traditional treatment based on hyperbaric oxygen, while the observation group was treated with the same as for the control group additionally with hormone. The clinical efficacy of two groups of patients was compared after the treatment. Results The total efficiency and Barthel index score and MMSE score of the observation group were significantly higher than those of the control group, and the differences had statistical significance(P﹤0. 01). Conclusion The treatment of hormone combined with hyperbaric oxygen has significant effect for delayed encephalopathy after acute carbon monoxide poisoning, which can significantly improve the cognitive function and activities of daily life in patients.%目的：探讨激素联合高压氧治疗急性一氧化碳中毒迟发性脑病的疗效。方法选取2010年6月至2014年1月于我院神经内科住院确诊的一氧化碳中毒迟发性脑病患者80例，随机分为观察组和对照组各40例。对照组采用以高压氧为主的传统治疗，观察组在对照组的基础上联合使用激素治疗，治疗结束后比较两组患者的临床疗效。结果观察组总有效率明显高于对照组，观察组Barthel指数评分及MMSE评分均明显高于对照组，上述结果差异均具有统计学意义(P<0.01)。结论激素联合高压氧治疗一氧化碳中毒迟发性脑病疗效显著，可明显提高患者的认知功能和日常活动能力，是临床较理想的治疗方法。