Objective: To observe the effect of high dose hormone combined with hyperbaric oxygen on delayed encephalopathy caused by acute carbon monoxide poisoning. Methods: 30 cases of delayed encephalopathy caused by acute carbon monoxide poisoning admitted from February 2016 to December 2017 in our hospital were analyzed. The patients were divided into control group and treatment group by randomized controlled clinical trial. Hyperbaric oxygen therapy and methylprednisolone combined with hyperbaric oxygen therapy were given respectively. The clinical cure rate, MMSE and Barthel were assessed before and after treatment. The therapeutic effects of the two groups were compared. Results: The effective rate of the treatment group was 73. 33％ higher than that of the control group (53. 33％) . The MMSE (25. 52 ±2. 22) and Barthel (71. 11 ± 6. 67) indexes of the treatment group were higher than those of the control group (20. 80 ± 1. 04) and Barthel (62. 51 ± 5. 02) . The difference was statistically significant (P < 0. 05) . Conclusion: it can improve the curative effect and prognosis of delayed encephalopathy caused by carbon monoxide poisoning by combining hormone therapy with hyperbaric oxygen therapy.%目的:观察大剂量激素联合高压氧治疗急性一氧化碳中毒迟发性脑病的疗效.方法:分析来自江西省景德镇二院2016年2月～2017年12月急诊科收治确诊为急性一氧化碳中毒出现迟发性脑病患者30例, 采用随机对照临床试验, 分为对照组与治疗组, 对应给予高压氧治疗及激素药物 (甲基强的松龙) 联合高压氧治疗.治疗前后对患者进行临床治愈率, 简易精神状态量表 (MMSE) , 日常生活活动能力指数 (Barthel) 评定, 对比两组治疗效果.结果:治疗组患者有效率73. 33％明显高于对照组53. 33％, 治疗组MMSE (25. 52±2. 22) , Barthel (71. 11±6. 67) 指标均高于对照组MMSE (20. 80±1. 04) , Barthel (62. 51±5. 02) .两者有统计学差异意义 (P <0. 05) ;结论:对于一氧化碳中毒迟发性脑病在高压氧治疗的基础上联合激素药物治疗, 可明显提高疗效, 改善患者预后.
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