围产期心肌病发病机制和诊治进展

摘要

Peripartum cardiomyopathy (PPCM) occurred before or after pregnant women , and cardiomyopathy is the basic characteris -tics. Congestive heart failure is the main clinical manifestations . The cause and pathogenesis of PPCM is unknown , and it may be related to virus infection, autoimmune reactions , hemodynamic abnormalities , malnutrition or etc. The diagnosis must rule out other common causes of heart failure, such as ischemic cardiomyopathy , hypertensive heart disease , valvular disease, etc. Echocardiography inspection have the val -ue. The early diagnosis of PPCM and standardized treatment of heart failure are very important . Cardiac function can be completely restored to normal. The fatality rate of PPCM is 5% ～ 32% , and the clinical outcomes are related to the left ventricular size and the recovery degree of cardiac function.%围产期心肌病(PPCM)是指发生在孕妇分娩前或后,首发以心肌病变为基本特征及充血性心力衰竭为主要临床表现的心脏病变.PPCM病因和发病机制不明,可能与病毒感染、自身免疫反应、血流动力学异常、营养不良等因素有关.诊断需排除导致心力衰竭的其他常见病因,如缺血性心肌病、高血压性心脏病、瓣膜病等,超声心动图检查有确诊价值.PPCM早期诊断和规范化心力衰竭治疗,心脏功能可完全恢复正常.PPCM患者病死率为5%~32%,临床预后与左心室大小及心功能的恢复程度相关.