2型糖尿病与阻塞性睡眠呼吸暂停低通气综合征的相关性研究

摘要

Objective:To investigate the correlation between type 2 diabetes mellitus(DM2) and obstructive sleep apnea hypopnea syndrome(OSAHS).Methods:Sixty patients of DM2 admitted to our department were included between June of 2015 and 2016,and equally randomized into simple DM2 group and DM2 with OSAHS group,another 30 patients in the corresponding period were recruited from the Otolaryngology Department of Yijshan Hospital,Wannan Medical College,as OSAHS group.Patients with OSAHS received polysomnography(PSG) and measurement of neck and waist circumference as well as body weight and height,and those with DM2 were given test on the levels of fasting blood glucose(FBG),low density lipoprotein cholesterol (LDL-C),cholesterol (CHO),triglyceride (TG),glycolsylated hemoglobin (HbA1c),fasting insulin (Fins) and recorded on the duration of diabetes.Results:Patients in the DM2 group and DM2 with OSAHS group had no statistical difference regarding the LDL-C,CHO,FBG,TG and duration of diabetes (P>0.05),yet HbA1c,Fins and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index were significantly different (P<0.05).The indicators,including the lowest oxygen saturation(LSpO2),AHI and BMI,were significantly different in patients in the OSAHS group and DM with OSAHS group (P<0.05),whereas the circumference of the neck and waist remained no difference (P>0.05).Conclusion:DM2 and OSAHS may affect each other,for which clinical diagnosis and treatment should take the synergy of the two entities into consideration in order to improve the treatment effects.%目的:研究2型糖尿病(DM)与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)间的相关性.方法:选取2015年6月～2016年6月入住芜湖市中医医院肾脏内分泌科的2型糖尿病患者共60例(其中合并OSAHS者30例),平分为DM组和DM合并OSAHS组;在同一时间,随机选取入住弋矶山医院耳鼻喉头颈外科的OSAHS患者30例,作为OSAHS组.对诊断有OSAHS的患者均行PSG检测,并测量颈围、腰围、体质量及身高;对2型糖尿病患者记录空腹血糖(FBG)、低密度脂蛋白(LDL-C)、胆固醇(CHO)、甘油三酯(TG)、糖化血红蛋白(HbA1c)、空腹胰岛素水平(Fins)和糖尿病病程等指标.结果:DM组和DM合并OSAHS组患者LDL-C、CHO、FBG、TG和糖尿病病程指标间无统计学意义(P>0.05),而HbA1c、Fins和HOMA-IR指标有统计学意义(P<0.05);OSAHS组和DM合并OSAHS组患者LSpO2、AHI和BMI指标间有统计学意义(P<0.05),但颈围和腰围指标间无统计学无意义(P>0.05).结论:2型糖尿病与OSAHS疾病相互影响、相互作用,因此临床诊治的过程中应充分考虑二者的协同作用,提高疾病的治愈率.