血清NSE水平与脑瘫患儿智能发育的相关性研究

摘要

Objective:To investigate the correlation of serum neuron-specific enolase(NSE) levels and intellectual development in children with cerebral palsy(CP).Methods:Serum NSE levels were measured in CP infants with high risks and healthy infants(control group) at day 7,the 3rd and 6th month after birth.Bayley Scales of Infant and Toddler Development was used to measure the mental development index(MDI) and psychomotor development index (PDI) at the 3rd month,and Gesell Developmental Schedules to evaluate the adaptive behavior,motion,fine motor,language and personal-social behavior at the sixth month.Then CP infants with high risks were divided into CP group and non-NCP group,and CP children were sub-grouped into the degree of low,moderate and high group based on the serum NSE levels measured at day 7 for comparative analysis.Results:①Serttm NSE levels differed in the control,CP and non-CP groups(P＜0.05).Serum NSE levels were decreased to a certain degree in children with CP at the 3rd and 6th month,yet NSE levels remained statistically different in three groups in the corresponding period(P＜0.05);②e scoring on MDI,PDI as well as motion,fine motor,language and social behavior was significantly reduced for children of CP at the 3rd month with elevatedNSE levels(P＜0.05);③ Correhtion analysis indicated that serum NSE levels in CP children at day 7,the 3rd and 6th month after birth were positively correlated with the scores of MDI and PDI at the 3rd month as well as motion,fine motor,language and social behavior at the 6th month (P＜0.05).Conclusion:Serum NSE levels at day 7,the 3rd and 6th month after birth are positively correlated with the intellectual development for children with CP.%目的:探讨脑瘫(CP)患儿血清神经元特异性烯醇化酶(NSE)水平与智能发育的相关性.方法:检测CP高危儿及健康儿(对照组)出生后第7天、3个月、6个月血清NSE水平,3个月时以贝利婴幼儿发育量表评价智力发展指数(MDI)及运动发展指数(PDI),6个月时以Gesell发育量表评价适应性行为、大运动、精细动作、语言和个人社会性行为,将CP高危儿分为CP组和非CP组;以第7天血清NSE水平按三分位法将CP患儿分为低、中、高3组进行比较.结果:①对照组、CP组与非CP组血清NSE水平差异有统计学意义(P＜0.05),CP患儿3个月、6个月时各组血清NSE水平均有所降低,但各组的同期NSE水平差异仍具有统计学意义(P＜0.05).②随着CP患儿NSE水平的升高,CP患儿3个月的MDI、PDI及6个月的大运动、精细动作、语言及社交行为评分均显著降低(P＜0.05).③相关性分析发现CP患儿出生后第7天、3个月与6个月血清NSE水平均与CP患儿3个月时的MDI、PDI,6个月时的大运动、精细动作、语言及社交行为有正相关性(P＜0.05).结论:CP儿出生后第7天、3个月与6个月的血清NSE水平与智能发育均具有正相关性.