Correlation study of serum Lp-PLA2 and NSE levels with nerve injury degree and lipid metabolism change in patients with acute cerebral infarction

摘要

Objective: To study the correlation of serum Lp-PLA2 and NSE levels with nerve injury degreeand lipid metabolism change in patients with acute cerebral infarction. Methods: Patientsdiagnosed with acute cerebral infarction in our hospital between March 2014 and October2016 were selected as the cerebral infarction group of the study, and healthy subjects receivingphysical examination during the same period were selected as control group. Serum wascollected to determine the levels of Lp-PLA2 and NSE as well as the content of nerve injurymolecules and lipid metabolism molecules. Results: Serum Lp-PLA2, NSE, NO, MDA, LPO,8-OHdG, ox-LDL, LDL-C and ApoB levels of cerebral infarction group were significantlyhigher than those of control group while HDL-C and ApoA1 content were significantly lowerthan those of control group; serum NO, MDA, LPO and 8-OHdG content of patients with NSE＞Q3 were significantly higher than those of patients with＜Q1, Q1-Q2 and Q2-Q3, serumNO, MDA, LPO and 8-OHdG content of patients with Q2-Q3 were significantly higher thanthose of patients with＜Q1 and Q1-Q2, and serum NO, MDA, LPO and 8-OHdG content ofpatients with Q1-Q2 were significantly higher than those of patients withQ1; serum ox-LDL,LDL-C and ApoB content of patients with Lp-PLA2＞Q3 were significantly higher than thoseof patients withQ1, Q1-Q2 and Q2-Q3 while HDL-C and ApoA1 content were significantlylower than those of patients withQ1, Q1-Q2 and Q2-Q3; serum ox-LDL, LDL-C and ApoBcontent of patients with Q2-Q3 were significantly higher than those of patients with Q1and Q1-Q2 while HDL-C and ApoA1 content were significantly lower than those of patientswithQ1 and Q1-Q2; serum ox-LDL, LDL-C and ApoB content of patients with Q1-Q2 weresignificantly higher than those of patients withQ1 while HDL-C and ApoA1 content weresignificantly lower than those of patients withQ1. Conclusion: Serum Lp-PLA2 and NSElevels increase significantly in patients with acute cerebral infarction, the increase of Lp-PLA2is associated with abnormal lipid metabolism, and the increase of NSE is associated withneural oxidative damage.