Comparative cytotoxicity and antioxidant evaluation of biologically active fatty acid conjugates of water soluble selenolanes in cells

摘要

Dihydroxy selenolane (DHS) and monoamine selenolan(MAS) are the synthetic water-soluble cyclic selenium (Se) analogues of dithiotheritol (Kumakura et al., 2010; Arai et al., 2014) (Fig. 1). These two compounds have been shown to exhibit wide range of biological activities such as free radical scavenging, mimicking the function of an antioxidant enzyme like glutathione peroxidise (GPx) and catalysing the oxidative folding of misfolded and/or denatured proteins (Singh et al., 2010; Kumakura et al., 2010; Chakraborty et al., 2012; Arai et al., 2011,2014).