FECAL D-/L-LACTATE CONCENTRATIONS AND ABUNDANCE OF LACTIC ACID BACTERIA IN DOGS WITH EXOCRINE PANCREATIC INSUFFICIENCY

摘要

Exocrine pancreatic insufficiency (EPI) in dogs is characterized by maldigestion as a result of inadequate synthesis and secretion of pancreatic enzymes. Previous studies have shown that dogs with EPI have small intestinal dysbiosis (SID) and may require concurrent antibiotic therapy in addition to pancreatic enzyme replacement therapy. In humans, patients with short bowel syndrome, which is also characterized by maldigestion and SID, have been reported to have increased fecal lactate concentrations.Therefore, the aim of this study was to compare the abundance of lactic acid-producing bacteria and D- and L-lactate concentrations in feces from healthy dogs (n=18), dogs undergoing enzyme replacement therapy for EPI (n=17), and untreated dogs with EPI (n=5).