Plasminogen purification with affinity membranes for ophthalmology applications

摘要

Some eye conditions like diabetic rethinopaty, macular pukers, retinal detachment may benefit from vitreoctomy. Enzymatic vitrectomy with plasmin is envisaged to augment or even replace conventional vitrectomy by proposed means of less surgical risks, less surgeon time, lower costs. In addition, the use of autologous plasmin is beneficial since avoid rejection problems and the search of compatible donors [1]. Plasmin has properties to hydrolize a variety of glycoproteins, including laminin and fibronectin, by degrading the links between these components of the vitreoretinal interface and the inner limiting membrane, therapeutic posterior vitreous detachment has become possible.