PURIFICATION OF PLASMINOGEN ACTIVATORS BY AFFINITY CHROMOTOGRAPHY

摘要

1. A process for the purification of a tissue plasminogen activator (t-PA), which comprises bringing a solution containing tissue plasminogen activator or one of its derivatives into contact with a carrier-bound polysulfate of a saccharide or sulfated sugar (affinity material), removal of the liquid, freeing the affinity material from impurities, and elutin t-PA, or t-PA derivative, bound by this material.