Lysozyme release from lipid-based implants

摘要

To better understand lipid-based implants applied to proteins, lysozyme was used as a model protein and was loaded into lipid-based implants in different contents. Cylindrical and spherical implants loaded with lysozyme presented a smooth surface. Protein loading efficiency decreased with increasing lysozyme loading. Lysozyme kept its activity after different implant preparation techniques. Drug release tremendously increased by increasing protein loading from 8.9 to 13.7% (w/w), for cylindrical implants. Lysozyme release was faster from cylindrical implants when compared with the spherical ones. Furthermore, by increasing the hydrophobicity of the lipid, protein release decreased. This study demonstrates the potential use of lipid-based implants for the controlled release of proteins.