固体脂质纳米粒和纳米结构脂质载体在药物传递中的研究进展

摘要

基于固体脂质的纳米粒（Solid lipid - based nanoparticles，SLBNs）作为新型药物传递系统比常规的药物传递系统存在优势。通常，基于固体脂质的纳米粒可以分成两种形态，即固体脂质纳米粒（ Solid lipid nanoparticles， SLNs）和纳米结构脂质载体（Nanostructured lipid carriers，NLCs）。但固体脂质纳米粒与纳米结构脂质载体在基质的组成上不同，本文就基于固体脂质的纳米粒的制备技术、表征方法及应用的最新研究进展进行总结，为基于固体脂质的纳米粒进一步研究提供参考依据。%Solid lipid - based nanoparticles(SLBNs)were developed as potential alternatives to other conventionaldrug delivery systems. In general,SLBNs are divided into two types:solid lipid nanoparticles(SLNs)and nanostructured lipid carriers(NLCs). SLNs are distinguishable from NLCs by the composition of solid particle matrix. This review provided an o-verview of the preparation and characterization technologies for SLBNs and using focuses on recent advances in drug delivery using SLBNs,providing the reference of SLNBs for further study.