METHOD FOR OBTAINING NANOSTRUCTURED LIPID CARRIERS, THE NANOSTRUCTURED LIPID CARRIERS OBTAINED AND USE THEREOF

摘要

The present invention relates to a method for obtaining nanostructured lipid carriers comprising buparvaquone coated with cationic and anionic polymers associated with a polypeptide using high-pressure homogenisation technology to promote electrostatic interaction between the components thereof in an aqueous medium. The present invention also relates to the aforementioned nanostructured lipid carriers obtained, which comprise 0.5 to 50% w/v oil phase, 1 to 10% w/v surfactant, 50 to 500,000 IU/ml of a polypeptide, 0.01 to 2% w/v of a cationic polymer; 0.04 to 5% w/v of an anionic polymer, and purified water QSP, thereby enabling site-specific release in macrophages, enabling the development of innovative medicines to improve the treatment of leishmaniasis.