AGENT FOR SUPPRESSING FORMATION OF LIPID PEROXIDE, AGENT FOR RELEASING LYSOZYME AND SUPPRESSING FORMATION OF ACTIVE OXYGEN, AND AGENT FOR SUPPRESSING RELEASE OF HISTAMINE

摘要

Disclosed are a method for the preparation of a drug for use in a treatment inhibiting the formation of lipid peroxide, the release of lysosome enzymes, the production of active oxygen, and/or the histamine release, a method for treatment of diseases associated with the formation of lipid peroxides, and, as an alternative of the invention, an improved method for the treatment of liver diseases, said methods comprising administering effective amounts of a compound of isoquinoline derivative represented by the general formula: …CHEM… or a salt thereof, in which Y indicates an oxygen or sulphur atom; R1, R2, R3, R6, R7, R8 and R9 independently indicate a hydrogen atom, a halogen atom, an alkyl group, a hydroxyl group, an alkoxy group, a halogen-substituted alkyl group, a thioalkoxy group, an amino group or a nitro group; or alternatively two adjacent groups R1 to R4 or R6 to R9 may together form a closed ring of alkylene group @(CH2)m wherein m is 3 or 4, or alkylene dioxy group …CHEM… wherein n is 1, 2 or 3;… and R5 indicates a hydrogen atom, an alkyl group, a hydroxyl group or an alkoxy group.